TERT Promoter Mutations Among Oral Cavity Cancers: A Pattern of Failure Analysis
نویسندگان
چکیده
منابع مشابه
Frequency of TERT promoter mutations in human cancers.
Reactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (w...
متن کاملHigh frequency of TERT promoter mutations in human cancers
Reactivation of telomerase has been implicated in human tumourigenesis, but the underlying mechanisms remain poorly understood. Here, we report the presence of recurrent somatic mutations in TERT promoter in cancers of the central nervous system, (43%), bladder (59%), thyroid (follicular cell-derived) (10%) and skin (melanoma, 29%). We also show that, in central nervous system and thyroid cance...
متن کاملHighly prevalent TERT promoter mutations in aggressive thyroid cancers.
Mutations 1 295 228 C>T and 1 295 250 C>T (termed C228T and C250T respectively), corresponding to -124 C>T and -146 C>T from the translation start site in the promoter of the telomerase reverse transcriptase (TERT) gene, have recently been reported in human cancers, but not in thyroid cancers yet. We explored these mutations in thyroid cancers by genomic sequencing of a large number of primary ...
متن کاملTERT Promoter Mutations in Thyroid Cancer.
Two mutations (C228T and C250T) in the promoter region of the telomerase reverse transcriptase (TERT) have recently been described in different types of cancer including follicular cell-derived thyroid cancer (TC). In this paper, we reviewed the rates of these mutations in different types and subtypes of TC, their association with a number of clinical and histopathological features and outcome ...
متن کاملUnderstanding TERT Promoter Mutations: A Common Path to Immortality.
Telomerase (TERT) activation is a fundamental step in tumorigenesis. By maintaining telomere length, telomerase relieves a main barrier on cellular lifespan, enabling limitless proliferation driven by oncogenes. The recently discovered, highly recurrent mutations in the promoter of TERT are found in over 50 cancer types, and are the most common mutation in many cancers. Transcriptional activati...
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ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2019
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2019.06.1604